<p>Dear Editor:</p>
<p>Please find enclosed a manuscript entitled: “Renal Tubular Dysfunction Linked to Tenofovir in Antiretroviral Therapy in HIV-Infected Patients” which I am submitting for exclusive consideration of publication as an article.</p>
<p>The article demonstrates the prevalence of RTD in the people living with HIV on TDF treatment, identify the risk factors associated and compare the 24-hours urine methods with the serum creatinine and its calculated clearance for the RTD identification. It is an important issue due to tenofovir is largerly used in developing and poor countries, in which tenofovir alafenamide is not avaiable.</p>
<p>Thank you for your consideration of my work!</p>