Analyzes of Knowledge, Attitude, and Practice of Turkish Midwives and Puerperal Women Regarding Pharmacovigilance


  • Yusuf Ergün Kahramanmaraş Sütçü İmam University, School of Medicine, Department of Pharmacology, Clinical Pharmacology Unit, Kahramanmaraş, Turkey
  • Eylem Toker Kahramanmaraş Sütçü İmam University, School of Health, Department of Midwifery, Kahramanmaraş, Turkey.
  • Mine Akben Kahramanmaraş Sütçü İmam University, School of Health, Department of Midwifery, Kahramanmaraş, Turkey.
  • Tansel Bekiroğlu Ergün Kahramanmaraş Sütçü İmam University, School of Health, Department of Midwifery, Kahramanmaraş, Turkey.



Attitude, Midwives, Knowledge, Pharmacovigilance, Practice, Puerperal Women


Spontaneous reporting of adverse drug reactions (ADRs) is the backbone of the pharmacovigilance system. However, underreporting is still a fundamental hurdle around the globe that must be resolved. To analyze Turkish midwives' and puerperal women's knowledge, attitude, and practice regarding pharmacovigilance. A cross-sectional study on midwives (n=36) and puerperal women (n=227) was carried out from September 2019 to June 2020 in a State Hospital in Turkey. Data were collected by a questionnaire and analyzed by Mann-Whitney U, Kruskal-Wallis, and the Chi-Square tests. The knowledge level of midwives was significantly higher than that of the puerperal women. Although all midwives knew of adverse drug reactions, only half of the puerperal women had heard this. The awareness of the pharmacovigilance term was 97% and 2% in midwives and puerperal women, respectively. Similarly, 81% of the midwives were aware of the Turkish Pharmacovigilance Center (TPC), whereas only 1% of the puerperal women realized the fact. More than half of the midwives knew they could directly report ADRs to TPC. However, most did not know how they could send or report ADRs. Interestingly, only five midwives knew that congenital anomalies and congenital disabilities had been included in ADRs. Although the knowledge, attitude, and practice of Turkish midwives were significantly better than puerperal women regarding pharmacovigilance, it is apparent that both groups were insufficient to get involved in the pharmacovigilance system properly.


World Health Organization. Quality Assurance and Safety of Medicines Team. (?2002)?. Safety of medicines: a guide to detecting and reporting adverse drug reactions: why health professionals need to take action. World Health Organization.

Campbell JE, Gossell-Williams M, Lee MG. A Review of Pharmacovigilance. West Indian Med J, 2014; 63(7): 771-774. doi:10.7727/wimj.2013.251.

Ozcan G, Aykac E, Kasap Y, Nemutlu NT, Sen E, Aydinkarahaliloglu ND. Adverse Drug Reaction Reporting Pattern in Turkey: Analysis of the National Database in the Context of the First Pharmacovigilance Legislation. Drugs Real World Outcomes, 2016; 3(1): 33-43. doi:10.1007/s40801-015-0054-1

Alan S, Ozturk M, Gokyildiz S, Avcibay B, Karata? Y. An evaluation of knowledge of pharmacovigilance among nurses and midwives in Turkey [published correction appears in Indian J Pharmacol. 2014 Jan-Feb;46(1):126]. Indian J Pharmacol, 2013; 45(6): 616-618. doi:10.4103/0253-7613.121375

Kassa Alemu B, Biru TT. Health Care Professionals' Knowledge, Attitude, and Practice towards Adverse Drug Reaction Reporting and Associated Factors at Selected Public Hospitals in Northeast Ethiopia: A Cross-Sectional Study. Biomed Res Int, 2019; 2019: 8690546. Published 2019 Nov 30. doi:10.1155/2019/8690546

Eric B, Jean T. Auguste A, Pocket E. Perception of Pharmacovigilance by Nurses and Midwives of the Cocody University Teaching Hospital in Abidjan. Pharmacology & Pharmacy, 2019; 10: 474-483. Doi: 10.4236/pp.2019.1011039

Inácio P, Cavaco A, Airaksinen M. The value of patient reporting to the pharmacovigilance system: a systematic review. Br J Clin Pharmacol, 2017; 83(2): 227-246. doi:10.1111/bcp.13098

Ergün Y, Ergün TB, Toker E, Ünal E, Akben M. Knowledge attitude and practice of Turkish health professionals towards pharmacovigilance in a university hospital. Int Health, 2019; 11(3): 177-184. doi:10.1093/inthealth/ihy073

Alshammari TM, Alamri KK, Ghawa YA, Alohali NF, Abualkol SA, Aljadhey HS. Knowledge and attitude of healthcare professionals in hospitals towards pharmacovigilance in Saudi Arabia. Int J Clin Pharm, 2015; 37(6): 1104-1110. doi:10.1007/s11096-015-0165-5

Adisa R, Omitogun TI. Awareness, knowledge, attitude and practise of adverse drug reaction reporting among health workers and patients in selected primary healthcare centres in Ibadan, southwestern Nigeria. BMC Health Serv Res, 2019; 19(1): 926. Published 2019 Dec 3. doi:10.1186/s12913-019-4775-9

Durrieu G, Hurault C, Damase-Michel C, Montastruc JL. Perception of risk of adverse drug reactions: a 3-year follow-up of a cohort of medical students. Fundam Clin Pharmacol, 2010; 24(4): 423-427. doi:10.1111/j.1472-8206.2009.00783.x

Chhabra KG, Sharma A, Chhabra C, Reddy JJ, Deolia SG, Mittal Y. Knowledge, Attitude, and Practices regarding Pharmacovigilance and Adverse Drug Reaction reporting among Dental Students in a Teaching Hospital, Jodhpur, India: A Cross-sectional Study. J Contemp Dent Pract, 2017; 18(10): 964-969. Published 2017 Oct 1. doi:10.5005/jp-journals-10024-2157

Othman GQ, Ibrahim MIM, Alshakka M, Ansari M, Al-Qadasi F, Halboup AM. Knowledge and Perception about Pharmacovigilance among Pharmacy Students of Universities in Sana'a Yemen. J Clin Diagn Res, 2017; 11(6): FC09-FC13. doi:10.7860/JCDR/2017/24228.10028

Omer QBA, Ramadan ME, Avan SS, Diana YY, Hala WA, Narmin OS. Pharmacovigilance Knowledge and Perceptions Among Pharmacy, Medical and Nurse Students in the University of Duhok. J Pharm Pract and Com Med, 2018; 4(2): 60-65. doi: 10.5530/jppcm.2018.2.16

Opadeyi AO, Fourrier-Réglat A, Isah AO. An educational intervention to improve healthcare professionals' knowledge, attitude and practice regarding pharmacovigilance in South-South Nigeria. Ther Adv Drug Saf, 2019; 10: 2042098618816279. Published 2019 Jan 25. doi:10.1177/2042098618816279

Jha N, Rathore DS, Shankar PR, et al. Effect of an educational intervention on knowledge and attitude regarding pharmacovigilance and consumer pharmacovigilance among community pharmacists in Lalitpur district, Nepal. BMC Res Notes, 2017; 10(1): 4. Published 2017 Jan 3. doi:10.1186/s13104-016-2343-5.




How to Cite

Ergün, Y., Toker, E. ., Akben, M. ., & Bekiroğlu Ergün, T. . (2022). Analyzes of Knowledge, Attitude, and Practice of Turkish Midwives and Puerperal Women Regarding Pharmacovigilance. Tropical Health and Medical Research, 4(1).